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KMID : 1103920090150030370
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Korean Journal of Hepatology
2009 Volume.15 No. 3 p.370 ~ p.374
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A case of sudden-onset hearing loss in a patient treated with peginterferon α-2b and ribavirin for chronic hepatitis C
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Shin Min-Ki
Kim Tae-Hyo
Ju Kang
Ha Chang-Yoon
Min Hyun-Ju
Jung Woon-Tae
Lee Ok-Jae
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Abstract
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Combination therapy of pegylated interferon α and ribavirin has been associated with various adverse effects, but sudden-onset hearing loss is uncommon. We report a 60-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon α and ribavirin for chronic hepatitis C. This patient had been diagnosed with chronic hepatitis C (genotype Ib) and early-stage liver cirrhosis 3 years previously, and had been treated with conventional interferon-α and ribavirin for 12 months. However, 6 months from the end of the treatment course the patient relapsed and received combination retreatment with pegylated interferon α-2b and ribavirin. He developed sudden-onset right-side hearing loss and tinnitus 42 weeks after the start of this retreatment. Pure-tone audiometry revealed a right-side hearing loss of 60~90dB. The patient consequently immediately discontinued the pegylated interferon therapy and was given prednisone 60 mg/day for 10 days, after which the hearing loss had almost completely recovered.
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KEYWORD
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Chronic hepatitis C, Peginterferon alfa-2b, Hearing loss, Sudden, Adverse effects
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